Nanoparticles of the poly([N-(2-hydroxypropyl)]-methacrylamide)-b-poly[2-(diisopropylamino)et hyl methacrylate] diblock copolymer for pH-triggered release of paclitaxel

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315453" target="_blank" >RIV/00216208:11310/15:10315453 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/15:00445417
Result on the web
<a href="http://dx.doi.org/10.1039/c5py00567a" target="_blank" >http://dx.doi.org/10.1039/c5py00567a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c5py00567a" target="_blank" >10.1039/c5py00567a</a>

Result language
angličtina
Original language name
Nanoparticles of the poly([N-(2-hydroxypropyl)]-methacrylamide)-b-poly[2-(diisopropylamino)et hyl methacrylate] diblock copolymer for pH-triggered release of paclitaxel
Original language description
The potential of self-assembled nanoparticles (NPs) containing the fine tunable pH-responsive properties of the hydrophobic poly[2-(diisopropylamino)ethyl methacrylate] (PDPA) core and the protein repellence of the hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) shell for in vitro cytostatic activity has been explored on cancer cells. The amphiphilic diblock copolymer poly[N-(2-hydroxypropyl) methacrylamide]-b-poly[2-(diisopropylamino)ethyl methacrylate] (PHPMA-b-PDPA) synthesized by a reversible addition-fragmentation chain transfer (RAFT) technique allows for excellent control of the polymer chain length for methacrylamides. The PHPMA-b-PDPA block copolymer dissolved in an organic solvent (ethanol/dimethylformamide) undergoes nanoprecipitation in phosphate buffer saline (PBS, pH similar to 7.4) and self-assembles into regular spherical NPs after solvent elimination. The NPs' structure was characterized in detail by dynamic (DLS), static (SLS) and electrophoretic (ELS) lig
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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