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Chitosan hydrogels enriched with polyphenols: Antibacterial activity, cell adhesion and growth and mineralization

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10316484" target="_blank" >RIV/00216208:11310/15:10316484 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985823:_____/15:00444733

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0144861715003598" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0144861715003598</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.carbpol.2015.04.043" target="_blank" >10.1016/j.carbpol.2015.04.043</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Chitosan hydrogels enriched with polyphenols: Antibacterial activity, cell adhesion and growth and mineralization

  • Original language description

    Injectable hydrogels for bone regeneration consisting of chitosan, sodium beta-glycerophosphate (Na beta-GP) and alkaline phosphatase (ALP) were enriched with the polyphenols phloroglucinol (PG) and gallic acid (GA) and characterized physicochemically and biologically with respect to properties relevant for applications in bone regeneration, namely gelation kinetics, mineralizability, antioxidant properties, antibacterial activity, cytocompatibility and ability to support adhesion and growth of human osteoblast-like MG63 cells. Enrichment with PG and GA had no negative effect on gelation kinetics and mineralizability. PG and GA both enhanced antioxidant activity of unmineralized hydrogels. Mineralization reduced antioxidant activity of hydrogels containing GA. Hydrogels containing GA, PG and without polyphenols reduced colony forming ability of Escherichia coli after 1 h, 3 h and 6 h incubation and slowed E. coli growth in liquid culture for 150 min. Hydrogels containing GA were cytotoxic and supported cell growth more poorly than polyphenol-free hydrogels. PG had no negative effect on cell adhesion and growth. (C) 2015 Elsevier Ltd. All rights reserved.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EI - Biotechnology and bionics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Carbohydrate Polymers

  • ISSN

    0144-8617

  • e-ISSN

  • Volume of the periodical

    129

  • Issue of the periodical within the volume

    SEPTEMBER 2015

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    135-142

  • UT code for WoS article

    000356746000018

  • EID of the result in the Scopus database

    2-s2.0-84929335296