Chitosan hydrogels enriched with polyphenols: Antibacterial activity, cell adhesion and growth and mineralization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10316484" target="_blank" >RIV/00216208:11310/15:10316484 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/15:00444733
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0144861715003598" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0144861715003598</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2015.04.043" target="_blank" >10.1016/j.carbpol.2015.04.043</a>

Result language
angličtina
Original language name
Chitosan hydrogels enriched with polyphenols: Antibacterial activity, cell adhesion and growth and mineralization
Original language description
Injectable hydrogels for bone regeneration consisting of chitosan, sodium beta-glycerophosphate (Na beta-GP) and alkaline phosphatase (ALP) were enriched with the polyphenols phloroglucinol (PG) and gallic acid (GA) and characterized physicochemically and biologically with respect to properties relevant for applications in bone regeneration, namely gelation kinetics, mineralizability, antioxidant properties, antibacterial activity, cytocompatibility and ability to support adhesion and growth of human osteoblast-like MG63 cells. Enrichment with PG and GA had no negative effect on gelation kinetics and mineralizability. PG and GA both enhanced antioxidant activity of unmineralized hydrogels. Mineralization reduced antioxidant activity of hydrogels containing GA. Hydrogels containing GA, PG and without polyphenols reduced colony forming ability of Escherichia coli after 1 h, 3 h and 6 h incubation and slowed E. coli growth in liquid culture for 150 min. Hydrogels containing GA were cytotoxic and supported cell growth more poorly than polyphenol-free hydrogels. PG had no negative effect on cell adhesion and growth. (C) 2015 Elsevier Ltd. All rights reserved.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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