The Influence of the Combination of Carboxylate and Phosphinate Pendant Arms in 1,4,7-Triazacyclononane-Based Chelators on Their 68Ga Labelling Properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10319182" target="_blank" >RIV/00216208:11310/15:10319182 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3390/molecules200713112" target="_blank" >http://dx.doi.org/10.3390/molecules200713112</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules200713112" target="_blank" >10.3390/molecules200713112</a>
Alternative languages
Result language
angličtina
Original language name
The Influence of the Combination of Carboxylate and Phosphinate Pendant Arms in 1,4,7-Triazacyclononane-Based Chelators on Their 68Ga Labelling Properties
Original language description
In order to compare the coordination properties of 1,4,7-triazacyclononane (tacn) derivatives bearing varying numbers of phosphinic/ carboxylic acid pendant groups towards Ga-68, 1,4,7-triazacyclononane-7-acetic-1,4-bis(methylenephosphinic) acid (NOPA) and 1,4,7triazacyclononane-4,7-diacetic-1-[methylene(2-carboxyethyl) phosphinic] acid (NO2AP) were synthesized using Mannich reactions with trivalent or pentavalent forms of H-phosphinic acids as phosphorus components. Stepwise protonation constants logK(1-3) 12.06, 3.90 and 1.95, and stability constants with Ga-III and Cu-II, logK(GaL) 24.01 and logK(CuL) 16.66, were potentiometrically determined for NOPA. Both ligands were labelled with Ga-68 and compared with NOTA (tacn-N, N', N ''-triacetic acid) andNOPO, a TRAP-type [tacn-N, N', N ''-tris( methylenephosphinic acid)] chelator. At pH 3, NOPO and NOPA showed higher labelling efficiency (binding with lower ligand excess) at both room temperature and 95 degrees C, compared to NO2AP and
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA13-08336S" target="_blank" >GA13-08336S: Hybrid materials based on macrocyclic ligands for medical applications</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
13112-13126
UT code for WoS article
000368695400089
EID of the result in the Scopus database
2-s2.0-84938375640