Applications of Viral Nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10320537" target="_blank" >RIV/00216208:11310/15:10320537 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Applications of Viral Nanoparticles
Original language description
Polyomaviruses and papillomaviruses are small non-enveloped tumorigenic viruses. Since the early 1970s, the potential of empty polyoma viral particles as carriers of genes into mammalian cells has been recognized. Research into papillomaviruses has lagged behind due to the difficulty of their cultivation. DNA recombinant technology has helped to regain research interest in papillomaviruses, especially with the discovery of the presence of two types of human papillomaviruses (HPVs), HPV16 and 18, in human cervical tumors. Consequently, several studies have demonstrated that more than a dozen HPV types are important etiological agents in human cancer. These findings accelerated papillomavirus research and led to the development of virus-like particle (VLP) technology, mainly for vaccine production. On the contrary, well-known human polyomaviruses, BK virus (BKPyV) and JC virus (JCPyV) were never recognized as oncogenic in humans and research focused on non-human polyomaviruses as vectors
Czech name
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Czech description
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Project
<a href="/en/project/GA13-26115S" target="_blank" >GA13-26115S: Delivery of Polyomavirus genomes into the cell nucleus and interactions of their structural proteins in host cells</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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