Arginine deiminase pathway enzymes: evolutionary history in metamonads and other eukaryotes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10328992" target="_blank" >RIV/00216208:11310/16:10328992 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/16:00507528

Result on the web

<a href="http://dx.doi.org/10.1186/s12862-016-0771-4" target="_blank" >http://dx.doi.org/10.1186/s12862-016-0771-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12862-016-0771-4" target="_blank" >10.1186/s12862-016-0771-4</a>

Result language

angličtina

Original language name

Arginine deiminase pathway enzymes: evolutionary history in metamonads and other eukaryotes

Original language description

Background: Multiple prokaryotic lineages use the arginine deiminase (ADI) pathway for anaerobic energy production by arginine degradation. The distribution of this pathway among eukaryotes has been thought to be very limited, with only two specialized groups living in low oxygen environments (Parabasalia and Diplomonadida) known to possess the complete set of all three enzymes. We have performed an extensive survey of available sequence data in order to map the distribution of these enzymes among eukaryotes and to reconstruct their phylogenies. Results: We have found genes for the complete pathway in almost all examined representatives of Metamonada, the anaerobic protist group that includes parabasalids and diplomonads. Phylogenetic analyses indicate the presence of the complete pathway in the last common ancestor of metamonads and heterologous transformation experiments suggest its cytosolic localization in the metamonad ancestor. Outside Metamonada, the complete pathway occurs rarely, nevertheless, it was found in representatives of most major eukaryotic clades. Conclusions: Phylogenetic relationships of complete pathways are consistent with the presence of the Archaea-derived ADI pathway in the last common ancestor of all eukaryotes, although other evolutionary scenarios remain possible. The presence of the incomplete set of enzymes is relatively common among eukaryotes and it may be related to the fact that these enzymes are involved in other cellular processes, such as the ornithine-urea cycle. Single protein phylogenies suggest that the evolutionary history of all three enzymes has been shaped by frequent gene losses and horizontal transfers, which may sometimes be connected with their diverse roles in cellular metabolism.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Evolutionary Biology

ISSN

1471-2148

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

OCT 6 2016

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

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UT code for WoS article

000386024600001

EID of the result in the Scopus database

2-s2.0-84991058726