Enantioselective Synthesis of the Unsaturated Fragment of Callyspongiolide

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10332784" target="_blank" >RIV/00216208:11310/16:10332784 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/acs.orglett.6b02897" target="_blank" >http://dx.doi.org/10.1021/acs.orglett.6b02897</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.orglett.6b02897" target="_blank" >10.1021/acs.orglett.6b02897</a>

Result language
angličtina
Original language name
Enantioselective Synthesis of the Unsaturated Fragment of Callyspongiolide
Original language description
A synthesis of the unsaturated side chain of callyspongiolide has been accomplished from two chiral building blocks prepared by catalytic asymmetric procedures applied on simple starting materials. The synthesis of the chiral benzylic alcohol was based on an enantioselective aldol reaction of a substituted benzaldehyde catalyzed by a chiral amine, whereas the chiral homoallyl alcohol was prepared by the enantioselective crotylboration of iodomethacryl aldehyde catalyzed by a chiral phosphoric acid. Both fragments were joined together by using standard Sonogashira coupling conditions.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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