On the tear proteome of the house mouse (Mus musculus musculus) in relation to chemical signalling

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10361516" target="_blank" >RIV/00216208:11310/17:10361516 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.7717/peerj.3541" target="_blank" >http://dx.doi.org/10.7717/peerj.3541</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7717/peerj.3541" target="_blank" >10.7717/peerj.3541</a>

Result language

angličtina

Original language name

On the tear proteome of the house mouse (Mus musculus musculus) in relation to chemical signalling

Original language description

Mammalian tears are produced by lacrimal glands to protect eyes and may function in chemical communication and immunity. Recent studies on the house mouse chemical signalling revealed that major urinary proteins (MUPs) are not individually unique in Mus musculus musculus. This fact stimulated us to look for other sexually dimorphic proteins that may-in combination with MUPs-contribute to a pool of chemical signals in tears. MUPs and other lipocalins including odorant binding proteins (OBPs) have the capacity to selectively transport volatile organic compounds (VOCs) in their eight-stranded beta barrel, thus we have generated the tear proteome of the house mouse to detect a wider pool of proteins that may be involved in chemical signalling. We have detected significant male-biased (7.8%) and female-biased (7%) proteins in tears. Those proteins that showed the most elevated sexual dimorphisms were highly expressed and belong to MUP, OBP, ESP (i.e., exocrine gland-secreted peptides), arid SCG/ABP. secretoglobin) families. Thus, tears may have the potential to elicit sex-specific signals combination by different proteins. Some tear lipocalins are not sexually dimorphic-with MUP20/darcin and OBP6 being good examples-and because all proteins may flow with tears through nasolacrimal ducts to nasal and oral cavities we suggest that their roles are wider than originally thought. Also, we have also detected several sexually dimorphic bactericidal proteins, thus further supporting an idea that males and females may have adopted alternative strategies in controlling microbiota thus yielding different VOC profiles.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10613 - Zoology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PeerJ

ISSN

2167-8359

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

JUL

Country of publishing house

US - UNITED STATES

Number of pages

23

Pages from-to

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UT code for WoS article

000405265500006

EID of the result in the Scopus database

2-s2.0-85021856492