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Migrastatics - Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10364793" target="_blank" >RIV/00216208:11310/17:10364793 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216305:26620/17:PU123739

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.trecan.2017.04.008" target="_blank" >http://dx.doi.org/10.1016/j.trecan.2017.04.008</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.trecan.2017.04.008" target="_blank" >10.1016/j.trecan.2017.04.008</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Migrastatics - Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

  • Original language description

    In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term &apos;migrastatics&apos; for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers. Local invasion and metastasis, rather than clonal proliferation, are the dominant features of solid cancer. However, a specific category of anti-invasion and antimetastatic drugs is missing for treatment of solid cancer. We propose the term &apos;migrastatics&apos; for drugs interfering with all modes of cancer cell invasiveness and, consequently, with their ability to metastasize (e.g., inhibiting not only local invasion, but also extravasation and metastatic colonization).In solid cancer, drug resistance is the main cause of treatment failure, and is attributed to mutations of the target. Since targeting the cause, although academically desirable, may be futile, a pragmatic and near-term option is to move downstream, to common denominators of cell migration and/or invasion, such as actin polymerization and actomyosin-mediated contractility.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Trends in Cancer

  • ISSN

    2405-8033

  • e-ISSN

  • Volume of the periodical

    3

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    16

  • Pages from-to

    391-406

  • UT code for WoS article

    000425969500002

  • EID of the result in the Scopus database

    2-s2.0-85019948751