Migrastatics - Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10364793" target="_blank" >RIV/00216208:11310/17:10364793 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/17:PU123739

Result on the web

<a href="http://dx.doi.org/10.1016/j.trecan.2017.04.008" target="_blank" >http://dx.doi.org/10.1016/j.trecan.2017.04.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.trecan.2017.04.008" target="_blank" >10.1016/j.trecan.2017.04.008</a>

Result language

angličtina

Original language name

Migrastatics - Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

Original language description

In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term &apos;migrastatics&apos; for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers. Local invasion and metastasis, rather than clonal proliferation, are the dominant features of solid cancer. However, a specific category of anti-invasion and antimetastatic drugs is missing for treatment of solid cancer. We propose the term &apos;migrastatics&apos; for drugs interfering with all modes of cancer cell invasiveness and, consequently, with their ability to metastasize (e.g., inhibiting not only local invasion, but also extravasation and metastatic colonization).In solid cancer, drug resistance is the main cause of treatment failure, and is attributed to mutations of the target. Since targeting the cause, although academically desirable, may be futile, a pragmatic and near-term option is to move downstream, to common denominators of cell migration and/or invasion, such as actin polymerization and actomyosin-mediated contractility.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Trends in Cancer

ISSN

2405-8033

e-ISSN

—

Volume of the periodical

3

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

391-406

UT code for WoS article

000425969500002

EID of the result in the Scopus database

2-s2.0-85019948751