DOTA analogues with a phosphinate-iminodiacetate pendant arm: modification of the complex formation rate with a strongly chelating pendant

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10366409" target="_blank" >RIV/00216208:11310/17:10366409 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c7dt01797a" target="_blank" >http://dx.doi.org/10.1039/c7dt01797a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c7dt01797a" target="_blank" >10.1039/c7dt01797a</a>

Result language
angličtina
Original language name
DOTA analogues with a phosphinate-iminodiacetate pendant arm: modification of the complex formation rate with a strongly chelating pendant
Original language description
The new ligand H(6)do3aP(ida) combines the macrocyclic DOTA-like cavity and the open-chain iminodiacetate group connected through a coordinating phosphinate spacer. Its acid-base and coordination properties in solution were studied by potentiometry. Thermodynamic coordination characteristics of both chelating units are similar to those reported for H(4)dota and iminodiacetic acid themselves, respectively, so, macrocyclic and iminodiacetate units behave independently. The formation kinetics of the Ce(III)-H(6)do3aP(ida) complex was studied by UV-Vis spectrophotometry. Various out-of-cage intermediates were identified with 1:1, 1:2 and 2:1 ligand-to-metal ratios. The presence of the strongly coordinating iminodiacetate group significantly slows down the metal ion transfer into the macrocyclic cavity and, so, the formation of the in-cage complex is two orders of magnitude slower than that reported for the Ce(III)-H(4)dota system. The kinetic inertness of the [Ce(do3aP(ida))](3-) complex towards acid-assisted dissociation is comparable to that of the [Ce(dota)](-) complex. The coordination modes of the ligand are demonstrated in the solid-state structure of [Cu-4(do3aP(ida))(OH)(H2O)(4)]Cl center dot 7.5H2O.
Czech name
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Czech description
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Type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
<a href="/en/project/LTC17067" target="_blank" >LTC17067: Application of NMR relaxation and diffusion measurements to assess dynamics of complex molecular systems</a>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP) S - Specificky vyzkum na vysokych skolach I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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