How alkalinization drives fungal pathogenicity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10368121" target="_blank" >RIV/00216208:11310/17:10368121 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1371/journal.ppat.1006621" target="_blank" >http://dx.doi.org/10.1371/journal.ppat.1006621</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.ppat.1006621" target="_blank" >10.1371/journal.ppat.1006621</a>

Result language

angličtina

Original language name

How alkalinization drives fungal pathogenicity

Original language description

pH governs most, if not all, processes of life. In fungi, ambient pH acts as a potent regulator of growth and development [1]. Studies conducted primarily in the 2 model organisms Saccharomyces cerevisiae and Aspergillus nidulans have cemented our understanding of how fungi sense and respond to pH. More recently, pH has emerged as a key player in the control of fungal pathogenicity. Infections caused by fungi are often associated with a pH shift in the surrounding host tissue [2+-4]. Extracellular alkalinization contributes to fungal virulence, but the underlying mechanisms are not fully understood. Recent studies have revealed new and unexpected ways by which fungi induce host alkalinization to increase their infectious potential. Here, we provide a brief overview of the mechanisms that govern pH signaling in fungi and highlight how recent findings have advanced our understanding of pathogen-induced alkalinization and its role during infection. We also discuss the emerging view that intracellular pH (pHi) acts as a master switch to govern fungal development and pathogenicity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS Pathogens

ISSN

1553-7366

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

000416888500002

EID of the result in the Scopus database

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