PD-1/PD-L1 Blockade Therapy for Tumors with Downregulated MHC Class I Expression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10369493" target="_blank" >RIV/00216208:11310/17:10369493 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3390/ijms18061331" target="_blank" >http://dx.doi.org/10.3390/ijms18061331</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms18061331" target="_blank" >10.3390/ijms18061331</a>

Result language
angličtina
Original language name
PD-1/PD-L1 Blockade Therapy for Tumors with Downregulated MHC Class I Expression
Original language description
The therapy of different advanced-stage malignancies with monoclonal antibodies blocking programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling has had an impressive long-lasting effect in a portion of patients, but in most cases, this therapy was not successful, or a secondary resistance developed. To enhance its efficacy in treated patients, predictive biomarkers are searched for and various combination treatments are intensively investigated. As the downregulation of major histocompatibility complex (MHC) class I molecules is one of the most frequent mechanisms of tumor escape from the host's immunity, it should be considered in PD-1/PD-L1 checkpoint inhibition. The potential for the use of a PD-1/PD-L1 blockade in the treatment of tumors with aberrant MHC class I expression is discussed, and some strategies of combination therapy are suggested.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10600 - Biological sciences

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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