Bile acids: Electrochemical oxidation on bare electrodes after acid-induced dehydration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10368988" target="_blank" >RIV/00216208:11310/18:10368988 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.elecom.2017.11.024" target="_blank" >https://doi.org/10.1016/j.elecom.2017.11.024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.elecom.2017.11.024" target="_blank" >10.1016/j.elecom.2017.11.024</a>
Alternative languages
Result language
angličtina
Original language name
Bile acids: Electrochemical oxidation on bare electrodes after acid-induced dehydration
Original language description
Bile acids and sterols in general have long been considered practically inactive for direct redox processes. Herein, a novel way of electrochemical oxidation of primary bile acids is reported, involving an initial acid-induced dehydration step, as confirmed by capillary electrophoresis-mass spectrometry, thereby extending the electrochemical activity of the steroid core. Oxidation potentials were found to be ca + 1.2 V vs. Ag/AgNO3 in acetonitrile on boron doped diamond, glassy carbon, and platinum electrodes in a mixed acetonitrile-aqueous medium employing perchloric acid as a chemical reagent, and as a supporting electrolyte for the voltammetric measurements. The chemical step proved to be effective only for primary bile acids, possessing an axial 7 alpha-hydroxyl group, which is a prerequisite for providing a well-developed voltammetric signal. Preliminary results show that other steroids, e.g., cholesterol, can also be oxidized by employing a similar approach.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Center of novel approaches to bioanalysis and molecular diagnostics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Electrochemistry Communications
ISSN
1388-2481
e-ISSN
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Volume of the periodical
86
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
99-103
UT code for WoS article
000419834400022
EID of the result in the Scopus database
2-s2.0-85037137162