Enantioselective Synthesis of the C23-C33 Fragment of Aetheramide A and Its C32 Epimer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10371194" target="_blank" >RIV/00216208:11310/18:10371194 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ejoc.201701416" target="_blank" >http://dx.doi.org/10.1002/ejoc.201701416</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201701416" target="_blank" >10.1002/ejoc.201701416</a>

Result language
angličtina
Original language name
Enantioselective Synthesis of the C23-C33 Fragment of Aetheramide A and Its C32 Epimer
Original language description
The key aetheramide A intermediate with the natural (R,R,R) configuration along with the one having the unnatural (R,S,R) configuration was synthesized. The synthesis of both stereoisomers was accomplished by Suzuki coupling of two advanced chiral building blocks: (R,R)- and (R,S)-vinylboronates and an (R)-iodoalkene. The former was prepared from (R)-mandelic acid, and the latter was prepared by enantioselective allylation of 3-iodoacrylaldehyde.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GAP207%2F11%2F0587" target="_blank" >GAP207/11/0587: Development and Application of Catalysts Based on Chiral Bipyridine Scaffold</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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