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Development of a Ratiometric Fluorescent Probe with Two Reactive Sulfoxides for Monitoring the Activity of Methionine Sulfoxide Reductase A

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10374847" target="_blank" >RIV/00216208:11310/18:10374847 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1055/s-0036-1591888" target="_blank" >https://doi.org/10.1055/s-0036-1591888</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1055/s-0036-1591888" target="_blank" >10.1055/s-0036-1591888</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Development of a Ratiometric Fluorescent Probe with Two Reactive Sulfoxides for Monitoring the Activity of Methionine Sulfoxide Reductase A

  • Original language description

    Biological oxidation of methionine side chains in proteins is a process that affects the functions of many proteins. One of the key regulators of this signaling is the enzyme methionine sulfoxide reductase A (MsrA). MsrA is implicated in a number of diseases, but detailed understanding of its function is hindered by the lack of tools for monitoring the enzyme&apos;s activity. We have designed and synthesized a probe named (S, S)-Sulfox-2 that is based on a BODIPY fluorophore and is equipped with two chiral sulfoxide units of defined stereochemistry. (S, S)-Sulfox-2 is shown to be highly responsive to MsrA and allows tracing of the MsrA activity by a significant change in the fluorescence profile.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10401 - Organic chemistry

Result continuities

  • Project

    <a href="/en/project/GJ17-25897Y" target="_blank" >GJ17-25897Y: Development of Fluorescent Probes for Methionine Sulfoxide Reductase and Beyond</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Synthesis

  • ISSN

    0039-7881

  • e-ISSN

  • Volume of the periodical

    50

  • Issue of the periodical within the volume

    04

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    6

  • Pages from-to

    772-777

  • UT code for WoS article

    000424152700009

  • EID of the result in the Scopus database

    2-s2.0-85040793408