Development of a Ratiometric Fluorescent Probe with Two Reactive Sulfoxides for Monitoring the Activity of Methionine Sulfoxide Reductase A
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10374847" target="_blank" >RIV/00216208:11310/18:10374847 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1055/s-0036-1591888" target="_blank" >https://doi.org/10.1055/s-0036-1591888</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/s-0036-1591888" target="_blank" >10.1055/s-0036-1591888</a>
Alternative languages
Result language
angličtina
Original language name
Development of a Ratiometric Fluorescent Probe with Two Reactive Sulfoxides for Monitoring the Activity of Methionine Sulfoxide Reductase A
Original language description
Biological oxidation of methionine side chains in proteins is a process that affects the functions of many proteins. One of the key regulators of this signaling is the enzyme methionine sulfoxide reductase A (MsrA). MsrA is implicated in a number of diseases, but detailed understanding of its function is hindered by the lack of tools for monitoring the enzyme's activity. We have designed and synthesized a probe named (S, S)-Sulfox-2 that is based on a BODIPY fluorophore and is equipped with two chiral sulfoxide units of defined stereochemistry. (S, S)-Sulfox-2 is shown to be highly responsive to MsrA and allows tracing of the MsrA activity by a significant change in the fluorescence profile.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GJ17-25897Y" target="_blank" >GJ17-25897Y: Development of Fluorescent Probes for Methionine Sulfoxide Reductase and Beyond</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Synthesis
ISSN
0039-7881
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
04
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
772-777
UT code for WoS article
000424152700009
EID of the result in the Scopus database
2-s2.0-85040793408