Serological Evaluation of Cutaneous Leishmania tropica Infection in Northern Israel
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10376199" target="_blank" >RIV/00216208:11310/18:10376199 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.4269/ajtmh.17-0370" target="_blank" >https://doi.org/10.4269/ajtmh.17-0370</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4269/ajtmh.17-0370" target="_blank" >10.4269/ajtmh.17-0370</a>
Alternative languages
Result language
angličtina
Original language name
Serological Evaluation of Cutaneous Leishmania tropica Infection in Northern Israel
Original language description
Leishmania spp. are medically important unicellular parasites transmitted by phlebotomine sand flies. The World Health Organization recently highlighted the importance of reliable diagnostic tools for leishmaniasis. Our study of human infection was conducted in two endemic foci of Leishmania tropica in the Galilee region, northern Israel. Elevated anti-Leishmania antibodies were present in the majority (78.6%) of L. tropica-PCR positive individuals. Moreover, the enzyme-linked immunosorbent assay showed high sensitivity, specificity, and negative and positive predictive values (ranging between 73% and 79%), thus fulfilling the basic requirement for future development of a serodiagnostic and screening tool. The anti-sand fly saliva antibodies used as biomarkers of exposure reflected the composition of the local sand fly fauna as well as the abundance of individual species. High levels of antibodies against vector salivary proteins may further indicate frequent exposure to sand flies and consequently a higher probability of Leishmania transmission.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10600 - Biological sciences
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Tropical Medicine and Hygiene
ISSN
0002-9637
e-ISSN
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Volume of the periodical
98
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
139-141
UT code for WoS article
000430950900026
EID of the result in the Scopus database
2-s2.0-85040511054