The novel mathematical model for the quantitative analysis of antagonist-receptor interactions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F19%3A10405211" target="_blank" >RIV/00216208:11310/19:10405211 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/journal/toxicology-letters/vol/314/suppl/S" target="_blank" >https://www.sciencedirect.com/journal/toxicology-letters/vol/314/suppl/S</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The novel mathematical model for the quantitative analysis of antagonist-receptor interactions
Original language description
Simplification in the Gaddum equation often leads to an inaccurate estimation of the equilibrium dissociation constants of the competitive antagonists, which is the key characteristic of the receptor ligands. In our previous study, we described the development and validation of a new mathematical model for mixture toxicity. Using this model, we derived a novel form of the Gaddum equation which contains the original hill coefficient of the agonist.
Czech name
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Czech description
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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