Maternal RhD heterozygous genotype is associated with male biased secondary sex ratio

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10405466" target="_blank" >RIV/00216208:11310/20:10405466 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10405466 RIV/00064165:_____/20:10405466
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=PGGZd3xEQZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=PGGZd3xEQZ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.earlhumdev.2019.104864" target="_blank" >10.1016/j.earlhumdev.2019.104864</a>

Result language
angličtina
Original language name
Maternal RhD heterozygous genotype is associated with male biased secondary sex ratio
Original language description
Previous studies suggest that RhD positive heterozygotes express better health status than RhD positive homozygotes and especially RhD negative subjects. This also applies to pregnant women. According to the Trivers-Willard hypothesis, women in better physical condition should have more sons. The data was analysed using Chi-Square test for all women, separately for RhD positive and RhD negative women, and separately for primiparous and multiparous women. The effects of maternal weight as a continuous predictor and the RhD phenotype of newborn as a categorical predictor of newborn sex were evaluated by the generalized linear model (GLZ) separately for RhD positive and RhD negative women using binomial distribution and logit link function. Secondary sex ratio was significantly higher (P = 0.028) in RhD positive mothers who had RhD negative newborns, i.e., in heterozygotes (SR = 1.23), than in RhD positive mothers who had RhD positive newborns, i.e., in a mixed population of heterozygotes and homozygotes (SR = 1.00), especially in primiparous women (P = 0.013; SR = 1.37 and 0.99 resp.).
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project
<a href="/en/project/GA18-13692S" target="_blank" >GA18-13692S: Conservation of Rh Polymorphism in Modern Humans through Selection Favoring Heterozygotes – The Influence of the Genotype on Fertility and Viability</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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