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Biological activity of two novel zinc(II) complexes with NSAID mefenamic acid

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10410667" target="_blank" >RIV/00216208:11310/20:10410667 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JFt.nHjBX9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JFt.nHjBX9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s11696-019-01003-5" target="_blank" >10.1007/s11696-019-01003-5</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Biological activity of two novel zinc(II) complexes with NSAID mefenamic acid

  • Original language description

    Zinc(II) mefenamate [Zn(mef)(2)] (1) along with two novel Zn(II) crystalline complexes with Hmef (mefenamic acid) [Zn(dmso)(2)(mef)(2)] (2) and [Zn(cyclam)(mef)(2)] (3) were synthesized and characterized by infrared spectroscopy, elemental and thermal analysis. Crystal structures of complexes 2 and 3 were determined by single-crystal X-ray structure analysis. The biological activity of complexes was investigated using various methods. First, the ability of the complexes to scavenge radicals [2,2-diphenyl-1-picrylhydrazyl-DPPH and diammonium 2,2 &apos;-Azino-bis(3-ethylbenzothiazoline-6-sulfonate)-ABTS] was investigated, indicating selective scavenging activity of studied compounds for ABTS(center dot+) in comparison to DPPH center dot. The complexes 2 and 3 are more active than the free Hmef. Second, the interaction of the complexes with serum albumins was investigated and obtained binding constants are within optimal range for transport in bloodstream. Third, the interaction of complexes with fish sperm DNA (FS-DNA) was studied by UV-Vis titration and competitive binding studies with ethidium bromide (EB). The obtained values of binding constants calculated from UV-Vis measurements and fluorescence measurements, respectively, indicates the strongest binding for complex 3. Fourth, antimicrobial activity of compounds 1-3 was studied against bacteria (S. aureus and E. coli), yeast (C. parapsilosis) and filamentous fungi (R. oryzae, A. alternata, M. gypseum); complex 1 indicates highest activity against filamentous fungi R. oryzae and A. alternate whereas complex 2 displays highest antimicrobial activity against both Gram-positive and Gram-negative bacteria and yeast.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10402 - Inorganic and nuclear chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Chemical Papers

  • ISSN

    2585-7290

  • e-ISSN

  • Volume of the periodical

    74

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    16

  • Pages from-to

    1525-1540

  • UT code for WoS article

    000520851600016

  • EID of the result in the Scopus database

    2-s2.0-85076209179