Biological activity of two novel zinc(II) complexes with NSAID mefenamic acid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10410667" target="_blank" >RIV/00216208:11310/20:10410667 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JFt.nHjBX9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JFt.nHjBX9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11696-019-01003-5" target="_blank" >10.1007/s11696-019-01003-5</a>
Alternative languages
Result language
angličtina
Original language name
Biological activity of two novel zinc(II) complexes with NSAID mefenamic acid
Original language description
Zinc(II) mefenamate [Zn(mef)(2)] (1) along with two novel Zn(II) crystalline complexes with Hmef (mefenamic acid) [Zn(dmso)(2)(mef)(2)] (2) and [Zn(cyclam)(mef)(2)] (3) were synthesized and characterized by infrared spectroscopy, elemental and thermal analysis. Crystal structures of complexes 2 and 3 were determined by single-crystal X-ray structure analysis. The biological activity of complexes was investigated using various methods. First, the ability of the complexes to scavenge radicals [2,2-diphenyl-1-picrylhydrazyl-DPPH and diammonium 2,2 '-Azino-bis(3-ethylbenzothiazoline-6-sulfonate)-ABTS] was investigated, indicating selective scavenging activity of studied compounds for ABTS(center dot+) in comparison to DPPH center dot. The complexes 2 and 3 are more active than the free Hmef. Second, the interaction of the complexes with serum albumins was investigated and obtained binding constants are within optimal range for transport in bloodstream. Third, the interaction of complexes with fish sperm DNA (FS-DNA) was studied by UV-Vis titration and competitive binding studies with ethidium bromide (EB). The obtained values of binding constants calculated from UV-Vis measurements and fluorescence measurements, respectively, indicates the strongest binding for complex 3. Fourth, antimicrobial activity of compounds 1-3 was studied against bacteria (S. aureus and E. coli), yeast (C. parapsilosis) and filamentous fungi (R. oryzae, A. alternata, M. gypseum); complex 1 indicates highest activity against filamentous fungi R. oryzae and A. alternate whereas complex 2 displays highest antimicrobial activity against both Gram-positive and Gram-negative bacteria and yeast.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemical Papers
ISSN
2585-7290
e-ISSN
—
Volume of the periodical
74
Issue of the periodical within the volume
5
Country of publishing house
SK - SLOVAKIA
Number of pages
16
Pages from-to
1525-1540
UT code for WoS article
000520851600016
EID of the result in the Scopus database
2-s2.0-85076209179