Changing faces of stress: Impact of heat and arsenite treatment on the composition of stress granules

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10414167" target="_blank" >RIV/00216208:11310/20:10414167 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nusWpzV-fL" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nusWpzV-fL</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/wrna.1596" target="_blank" >10.1002/wrna.1596</a>

Result language

angličtina

Original language name

Changing faces of stress: Impact of heat and arsenite treatment on the composition of stress granules

Original language description

Stress granules (SGs), hallmarks of the cellular adaptation to stress, promote survival, conserve cellular energy, and are fully dissolved upon the cessation of stress treatment. Different stresses can initiate the assembly of SGs, but arsenite and heat are the best studied of these stresses. The composition of SGs and posttranslational modifications of SG proteins differ depending on the type and severity of the stress insult, methodology used, cell line, and presence of overexpressed and tagged proteins. A group of 18 proteins showing differential localization to SGs in heat- and arsenite-stressed mammalian cell lines is described. Upon severe and prolonged stress, physiological SGs transform into more solid protein aggregates that are no longer reversible and do not contain mRNA. Similar pathological inclusions are hallmarks of neurodegenerative diseases. SGs induced by heat stress are less dynamic than SGs induced by arsenite and contain a set of unique proteins and linkage-specific polyubiquitinated proteins. The same types of ubiquitin linkages have been found to contribute to the development of neurodegenerative disorders such as Parkinson disease, Alzheimer disease, and amyotrophic lateral sclerosis (ALS). We propose heat stress-induced SGs as a possible model of an intermediate stage along the transition from dynamic, fully reversible arsenite stress-induced SGs toward aberrant SGs, the hallmark of neurodegenerative diseases. Stress- and methodology-specific differences in the compositions of SGs and the transition of SGs to aberrant protein aggregates are discussed. This article is categorized under: RNA in Disease and Development &gt; RNA in Disease RNA Interactions with Proteins and Other Molecules &gt; RNA-Protein Complexes RNA Export and Localization &gt; RNA Localization

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10600 - Biological sciences

Project

<a href="/en/project/GA19-13491S" target="_blank" >GA19-13491S: In vitro oocyte culture vs in vivo oocyte development - is their physiology really comparable?</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Wiley interdisciplinary reviews. RNA

ISSN

1757-7004

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

26

Pages from-to

e1596

UT code for WoS article

000529788200001

EID of the result in the Scopus database

2-s2.0-85083838270