RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10414377" target="_blank" >RIV/00216208:11310/20:10414377 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/20:00538114
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QOk3iJNmKD" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QOk3iJNmKD</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/genes11020232" target="_blank" >10.3390/genes11020232</a>

Result language
angličtina
Original language name
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
Original language description
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10600 - Biological sciences

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)