Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10417274" target="_blank" >RIV/00216208:11310/20:10417274 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11410/20:10417274
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.inVghUAsn" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.inVghUAsn</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.31489/2020Ch1/35-42" target="_blank" >10.31489/2020Ch1/35-42</a>
Alternative languages
Result language
angličtina
Original language name
Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives
Original language description
This article provides results of evaluation of synthesized biologically active substances 1-4 antiradical activity according to their ability to interact with the 2,2- diphenyl-1-picrylhydrazyl radical (DPPH center dot). It was found that all synthesized compounds 1-4 have antiradical activity. Pronounced antiradical activity was shown by Nethyl-2-(2-hydroxybenzoyl)hydrazine-carbothioamide (1) (IC50(DPPH) = 12.5 mu Mu) and N-ethyl-2-(4-hydroxybenzoyl)hydrazine-carbothioamide (2) (IC50(DPPH) = 16.7 mu Mu) samples under the conditions of this test system. Activity of N-ethyl-2-(2-hydroxybenzoyl) hydrazinecarbothioamide (1) and N-ethyl-2-(4-hydroxybenzoyl)hydrazinecarbothioamide (2) samples are comparable to activity of known antioxidants. Studied substances 1 and 2 are promising for further advanced research of their antioxidant properties and other types of biological activity. Results of PASS computer system applicability estimation for prediction of biological activity using structural formula as a part of pre-experimental screening are provided. Expected activity of chemical compounds combines physiological activity of initial hydrazides of o- and p-hydroxybenzoic acids as well as components of structural molecule. According to bioprediction data analysis, all compounds can act as inhibitors with a high degree of probability.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bulletin of Karaganda State University, Series chemistry
ISSN
2518-718X
e-ISSN
—
Volume of the periodical
Neuveden
Issue of the periodical within the volume
97
Country of publishing house
KZ - KAZAKSTAN
Number of pages
8
Pages from-to
35-42
UT code for WoS article
000523428000004
EID of the result in the Scopus database
—