Increased 25(OH)D3 level in redheaded people: Could redheadedness be an adaptation to temperate climate?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10420721" target="_blank" >RIV/00216208:11310/20:10420721 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/20:N0000005
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bpgtShltvv" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bpgtShltvv</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/exd.14119" target="_blank" >10.1111/exd.14119</a>
Alternative languages
Result language
angličtina
Original language name
Increased 25(OH)D3 level in redheaded people: Could redheadedness be an adaptation to temperate climate?
Original language description
About 1-2% of European population are redheaded, meaning they synthesize more pheomelanin than eumelanin, the main melanin pigment in humans. Several muta- tions could be responsible for this phenotype. It has been suggested that corre- sponding mutations spread in Europe due to a founder effect shaped either by a relaxation of selection for dark, UV-protective phenotypes or by sexual selection in favour of rare phenotypes. In our study, we investigated the levels of vitamin D precursor 25(OH)D3 (calcidiol) and folic acid in the blood serum of 73 redheaded and 130 non-redheaded individuals. In redheaded individuals, we found higher 25(OH)D3 concentrations and approximately the same folic acid concentrations as in non-red- headed subjects. 25(OH)D3 concentrations correlated with the intensity of hair red- ness measured by two spectrophotometric methods and estimated by participants themselves and by independent observers. In non-redheaded individuals, 25(OH)D3 levels covaried with the amount of sun exposure and intensity of suntan while in redheaded individuals, this was not the case. It suggests that increased 25(OH)D3 levels in redheaded individuals are due to differences in physiology rather than in behaviour. We also found that folic acid levels increased with age and the intensity of baldness and decreased with the frequency of visiting tanning salons. Our results suggest that the redheaded phenotype could be an evolutionary adaptation for suf- ficient photosynthesis of provitamin D in conditions of low intensity of UVB radiation in central and northern parts of Europe.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
<a href="/en/project/GA18-13692S" target="_blank" >GA18-13692S: Conservation of Rh Polymorphism in Modern Humans through Selection Favoring Heterozygotes – The Influence of the Genotype on Fertility and Viability</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Dermatology
ISSN
0906-6705
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
598-609
UT code for WoS article
000543087100001
EID of the result in the Scopus database
2-s2.0-85087170082