Synthesis and antimicrobial activity of novel kojyl carbamates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10457686" target="_blank" >RIV/00216208:11310/20:10457686 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KZqrBMA7pd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KZqrBMA7pd</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis and antimicrobial activity of novel kojyl carbamates
Original language description
Novel kojyl carbamates of amantadine, rimantadine and oseltamivir were synthesized and assayed to evaluate their antimicrobial activity. The newly compounds were prepared by using EDC/HOBt method at preliminary activation of kojic acid. The structures of the synthesized kojyl derivatives were confirmed by mp, UV, IR (ATR)umax, ESI-MS. According to the antimicrobial activity studies performed in vitro, kojyl carbamate of rimantadine (4) displayed the highest antibacterial activity (MIC: 31 μg/mL) against two Gram-positive (Staphylococcus aureus, Bacillus subtilis) bacteria. Moreover, this compound (4) showed about 4-fold better activity against two Gram-negative bacteria tested (Escherichia coli, Pseudomonas aeruginosa). Amongst the examined kojyl carbamates, the rimantadine derivative of kojic acid (4) exhibited the highest antifungal activity (Candida albicans) as well.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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