Synthesis of fused 1,2-naphthoquinones with cytotoxic activity using a one-pot three-step reaction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F21%3A10430734" target="_blank" >RIV/00216208:11310/21:10430734 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EUtixJQEw2" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EUtixJQEw2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d1ob00205h" target="_blank" >10.1039/d1ob00205h</a>

Result language
angličtina
Original language name
Synthesis of fused 1,2-naphthoquinones with cytotoxic activity using a one-pot three-step reaction
Original language description
A method for the synthesis of fused 1,2-naphthoquinones, as analogues of biologically active natural terpene quinones, is described. The intermediate polycyclic naphthalenes were prepared by a one-pot palladium-catalysed process from simple alkynes, one of which was made from an optically pure biomass-derived levoglucosenone. The prepared methoxy-substituted naphthalenes were subsequently transformed in one step to 1,2-naphthoquinones by a trivalent-iodine-mediated oxidation. The naphthoquinone products were found to have cytotoxic properties.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GJ16-22419Y" target="_blank" >GJ16-22419Y: Tandem cyclisation/Suzuki cross-coupling reaction and halocarbocyclisation as a means for enantioselective construction of quaternary carbon centres</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)