Organocatalytic Amination of Pyrazolones with Azodicarboxylates: Scope and Limitations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F21%3A10431538" target="_blank" >RIV/00216208:11310/21:10431538 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=E0FhYrdEkp" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=E0FhYrdEkp</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.202100167" target="_blank" >10.1002/ejoc.202100167</a>

Result language
angličtina
Original language name
Organocatalytic Amination of Pyrazolones with Azodicarboxylates: Scope and Limitations
Original language description
The organocatalytic amination of pyrazol-5-ones with azodicarboxylates (catalyzed by quinine) is reported. This asymmetric process furnishes enantiomerically enriched hydrazine adducts containing quaternary stereocenters in high yields (74-96 %) and enantioselectivities (up to ee 97 %). Theoretical calculations allow us to propose the relations between quinine catalyst and reactants leading to observed stereochemical outcome and trends in the effectivity of the reaction.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA20-29336S" target="_blank" >GA20-29336S: Enantioselective transformations using Brønsted acid catalysis and aminocatalysis (BACA)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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