Synthesis and self-assembly of polyzwitterionic phenylboronic acid-containing double hydrophilic block copolymers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F21%3A10436165" target="_blank" >RIV/00216208:11310/21:10436165 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=2VW0p2Stup" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=2VW0p2Stup</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2021.110439" target="_blank" >10.1016/j.eurpolymj.2021.110439</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and self-assembly of polyzwitterionic phenylboronic acid-containing double hydrophilic block copolymers
Original language description
Double hydrophilic block copolymers self-assemble into smart materials with promising applications in nano-medicine. However, such practical applications require thoroughly understanding the underlying mechanisms of this self-assembly process and the effects of external stimuli on the resulting materials. Thus, we report the post-polymerization modification of a pH-responsive double hydrophilic diblock copolymer (poly(ethylene oxide)-b-poly(4-vinyl pyridine)) by stimuli-responsive, diol-binding 2-bromomethyl-4-fluorophenylboronic acid and the comprehensive study of the self-assembly properties of this polyzwitterionic polymer for potential applications in the delivery of functional diols, including pharmaceutical drugs, steroids and sugars. For this purpose, we performed simple, robust and reproducible quaternization reactions at three different degrees (25, 50 and 100%) by varying the composition of the initial mixture and confirmed full control over the degree of quaternization by proton nuclear magnetic and infrared spectroscopy. Our results show that the degree of quaternization strongly affects the solubility of these polymers in basic solutions because PBA adopts a tetragonal conformation with a negative charge on boron at pH values higher than the pK(A) of PBA. Nevertheless, the specific PBA (anionic vs neutral) form of these polymers can be differentiated by B-11 NMR, regardless of the degree of quaternization. In turn, the pH of the solvent affected the intensity of the NMR signals, thus suggesting the formation of kinetically frozen nanoparticles, in line with the results from both static and dynamic light scattering, with no indication of particle dissociation at low concentrations. Moreover, electrophoretic light scattering showed linear, albeit opposite (direct and inverse) correlations between the degree of quaternization and the zeta potential in water and 0.1 M HCl, respectively. When adsorbed to a mica surface, these nanoparticles predominantly displayed globular shapes under atomic force microscopy. Therefore, our high-throughput and low-cost nanofabrication method combining the stimuli-responsive behavior of a double hydrophilic block copolymer with the unique chemical properties of pH-responsive diol-binding phenylboronic acid functional groups establishes an experimental paradigm for preparing nanocarriers for biomedical applications, such as targeted drug delivery.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/LTAIN19078" target="_blank" >LTAIN19078: Stimuli-Responsive Block Copolymer Based Nanostructured Single-/Multi-component Micelles: Materials and Applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Polymer Journal
ISSN
0014-3057
e-ISSN
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Volume of the periodical
151
Issue of the periodical within the volume
May
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
110439
UT code for WoS article
000646028400011
EID of the result in the Scopus database
2-s2.0-85104364735