Understanding the molecular bases of innate immune responses to foreign or mislocalized self-DNA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10454405" target="_blank" >RIV/00216208:11310/22:10454405 - isvavai.cz</a>
Result on the web
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/37" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/37</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Understanding the molecular bases of innate immune responses to foreign or mislocalized self-DNA
Original language description
We previously described that Murine polyomavirus MPyV induces type I interferon (IFN) responses via the sensors, p204 (human IFI16 homolog) and cGAS which sense viral genomes and micronucleus-like bodies generated during infection1. Sensing by both DNA sensors leads to canonical STING activation. During MPyV infection, there are additional cell responses are activated such as DNA damage response and apoptosis, therefore we investigated a possible contribution of the DNA damage in the activation of a STING non-canonical pathway and the role of sublethal apoptosis in the induction of innate immune responses to the infection by MPyV.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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