Enantioselective Synthesis of Spiro Heterocycles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10458296" target="_blank" >RIV/00216208:11310/22:10458296 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1002/9781119567646.ch7" target="_blank" >https://doi.org/10.1002/9781119567646.ch7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/9781119567646.ch7" target="_blank" >10.1002/9781119567646.ch7</a>

Result language

angličtina

Original language name

Enantioselective Synthesis of Spiro Heterocycles

Original language description

This chapter reviews catalytic synthetic methods allowing enantioselective construction of spiro heterocyclic compounds, excluding oxindole motif. It discusses the enantioselective methods for the construction of spirocycles with one heteroatom, such as nitrogen-containing heterocycles (pyrrolidine, indolizine, and piperidine), oxygen- and sulfur-containing heterocycles (furanone, benzofuranone, and pyrane). N-Heterocyclic carbene catalysis can be used for the enantioselective synthesis of spiroindolenines. Among catalytic approaches, asymmetric organocatalysis predominates in the preparation of chiral sulfur-containing spiro compounds. The organic chemists have studied catalytic approaches to synthesize chiral spirocyclic compounds containing more than one spiro atom; some of them led to structurally valuable substances. The chapter presents synthetic strategies for the preparation of chiral spirocycles containing more than one heteroatom, including pyrazolones, azlactones, barbituric acid derivatives, sultams. It also presents catalytic methods for enantioselective preparation of other types of spiro heterocycles and bispiro compounds.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

10401 - Organic chemistry

Project

<a href="/en/project/GA20-29336S" target="_blank" >GA20-29336S: Enantioselective transformations using Brønsted acid catalysis and aminocatalysis (BACA)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Spiro Compounds: Synthesis and Applications

ISBN

978-1-119-56763-9

Number of pages of the result

78

Pages from-to

205-282

Number of pages of the book

444

Publisher name

John Wiley &amp; Sons, Inc.

Place of publication

Hoboken, NJ

UT code for WoS chapter

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