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Mouse PML protein isoforms and their role in Mouse Polyomavirus infection

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10465730" target="_blank" >RIV/00216208:11310/23:10465730 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/23:10470047

  • Result on the web

    <a href="https://wbw27.wbworkshops.com/abstracts/" target="_blank" >https://wbw27.wbworkshops.com/abstracts/</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Mouse PML protein isoforms and their role in Mouse Polyomavirus infection

  • Original language description

    Promyelocytic leukaemia nuclear bodies (PML NBs) are dynamic, spherical, membrane-less structures composed of the main scaffold PML protein and a variety of stable or transient partner proteins. Apart from many endogenous functions, PML NBs play an important role in antiviral defence, both as direct restriction factors and regulators of the interferon responses. Hence, many viruses developed effective mechanisms to counteract this restriction. This project uses Mouse polyomavirus (MPyV) as a model for studying interactions of PML and viral components. The mouse PML (mPML) protein occurs in three confirmed (mPML1-3) and six predicted (mPMLX1-X6) isoforms. Individual isoforms may affect the composition and functions of PML NBs and mediate antiviral effects.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    10607 - Virology

Result continuities

  • Project

    <a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů