Synthesis of silver complexes with chelating bidentate N-heterocyclic ligands, their application in catalytic A(3) coupling, and as antimicrobial agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10465985" target="_blank" >RIV/00216208:11310/23:10465985 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=fTTfnpvbyK" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=fTTfnpvbyK</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/aoc.6994" target="_blank" >10.1002/aoc.6994</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of silver complexes with chelating bidentate N-heterocyclic ligands, their application in catalytic A(3) coupling, and as antimicrobial agents
Original language description
We present a synthesis of novel silver complexes stabilized by bidentate ligands based on N-heterocyclic carbenes (NHC) linked with a bisamide linker. The ligand stabilizes the silver ion in a rare chelating mode. The synthesis of the complex depends on the equimolar ratio of the silver source and the ligand precursor. In case the excess of the silver source is used, the reaction leads to the formation of an unprecedented tetranuclear silver complex, stabilized by two equivalents of the ligand, where each of the silver atoms is coordinated by one NHC and one amide moiety. The silver complexes were applied as a catalyst in a multicomponent A(3) coupling and proved to be a very efficient catalyst. The reaction provided desired products in yields up to 96%, and the use of low catalytic loading, as low as 0.1 mol%, was possible without significantly compromising the effectivity of the reaction. Moreover, the complexes showed broad spectra of antimicrobial activity, with minimal inhibitory concentrations in the range of 1 to 31 mu g/ml against several Gram-positive and Gram-negative bacteria and fungi. Presented complexes represent synthetically challenging molecules, which show great applicability in catalysis and outstanding potential as antimicrobial agents.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Organometallic Chemistry
ISSN
0268-2605
e-ISSN
1099-0739
Volume of the periodical
37
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
e6994
UT code for WoS article
000928873700001
EID of the result in the Scopus database
2-s2.0-85147492542