Discovery of Small Molecule Activators of NRF1 Transcriptional Activity Preventing Protein Aggregation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10471751" target="_blank" >RIV/00216208:11310/23:10471751 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Discovery of Small Molecule Activators of NRF1 Transcriptional Activity Preventing Protein Aggregation
Original language description
The intracellular accumulation of abnormal proteins exceeding their degradation can cause imbalance in proteostasis resulting in proteotoxic stress that leads to severe pathological stages. This state relates to proteasome saturation/ insufficiency which requires upregulation of proteasome subunits. Nuclear Factor Erythroid 2-related factor 1 (NRF1) is a transcription factor (encoded by NFE2L1) which activates proteasome gene re-synthesis upon impairment of the proteasome function. Therefore, targeted activation of the NRF1 pathway could represent a new approach to delay the onset neurodegenerative diseases and other disorders with disturbed proteostasis.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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