Role of E2/E3 ubiquitin ligase, UBE2O, in Hepatitis B virus replication

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10472311" target="_blank" >RIV/00216208:11310/23:10472311 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Role of E2/E3 ubiquitin ligase, UBE2O, in Hepatitis B virus replication
Original language description
Chronic hepatitis represents a life-long liver disease caused by infection of Hepatitis B virus (HBV) and affecting more than 250 million people worldwide. Since HBV replication is completely dependent upon host cell protein pathways, the study of virus-host interactions promises to reveal novel cellular targets for development of new therapies. Our strategy is to identify and characterize key cellular proteins and pathways that are essential for different steps of viral replication1,2. Using mass spectrometry, we identified a novel HBV Core (HBc) - interacting host protein, UBE2O3. UBE2O is an E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates mono-ubiquitination of several chromatin-associated proteins, such as INO80, BAP1 and CXXC1, affecting their subcellular location4. Notably, UBE2O is also implicated in endosomal protein trafficking through its ubiquitination of the WASH regulatory complex5.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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