miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486090" target="_blank" >RIV/00216208:11310/24:10486090 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV
Original language description
Hepatitis B virus (HBV) causes acute hepatitis and can lead to chronic liver inflammation, often resulting in hepatocellular carcinoma. Known as a stealth virus, virus," HBV can evade recognition by the immune system. Plasmacytoid dendritic cells (pDCs), robust producers of type I and III interferons (IFNs), 1 which are crucial for HBV clearance. However, miRNA146a, an immunosuppressive and proliferative miRNA in hepatocytes, modulates pDCs by silencing TRAF6 and IRAK1/4 proteins.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10600 - Biological sciences
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů