Deleterious phenotypes in wild Arabidopsis arenosa populations are common and linked to runs of homozygosity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486534" target="_blank" >RIV/00216208:11310/24:10486534 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=O5jrQBw6N8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=O5jrQBw6N8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/g3journal/jkad290" target="_blank" >10.1093/g3journal/jkad290</a>
Alternative languages
Result language
angličtina
Original language name
Deleterious phenotypes in wild Arabidopsis arenosa populations are common and linked to runs of homozygosity
Original language description
In this study, we aimed to systematically assess the frequency at which potentially deleterious phenotypes appear in natural populations of the outcrossing model plant Arabidopsis arenosa, and to establish their underlying genetics. For this purpose, we collected seeds from wild A. arenosa populations and screened over 2,500 plants for unusual phenotypes in the greenhouse. We repeatedly found plants with obvious phenotypic defects, such as small stature and necrotic or chlorotic leaves, among first-generation progeny of wild A. arenosa plants. Such abnormal plants were present in about 10% of maternal sibships, with multiple plants with similar phenotypes in each of these sibships, pointing to a genetic basis of the observed defects. A combination of transcriptome profiling, linkage mapping and genome-wide runs of homozygosity patterns using a newly assembled reference genome indicated a range of underlying genetic architectures associated with phenotypic abnormalities. This included evidence for homozygosity of certain genomic regions, consistent with alleles that are identical by descent being responsible for these defects. Our observations suggest that deleterious alleles with different genetic architectures are segregating at appreciable frequencies in wild A. arenosa populations.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/GA20-22783S" target="_blank" >GA20-22783S: Genome duplication as an imperfect barrier in speciation? Evolutionary drivers and consequences of inter-ploidy introgression in natural populations</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
G3-Genes Genomes Genetics
ISSN
2160-1836
e-ISSN
2160-1836
Volume of the periodical
14
Issue of the periodical within the volume
3
Country of publishing house
IT - ITALY
Number of pages
13
Pages from-to
jkad290
UT code for WoS article
001145456700001
EID of the result in the Scopus database
2-s2.0-85189485085