Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10487183" target="_blank" >RIV/00216208:11310/24:10487183 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=P1bFhwZ0M-" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=P1bFhwZ0M-</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ceb.2023.102302" target="_blank" >10.1016/j.ceb.2023.102302</a>
Alternative languages
Result language
angličtina
Original language name
Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome
Original language description
Notch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch ligand 1 (JAG1), and manifests with liver disease and cardiovascular symptoms that are a direct consequence of JAG1 haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental and homeostatic processes explain how pathology develops in the hepatic and cardiovascular systems and, together with recent elucidation of mechanisms modulating liver regeneration, provide a basis for therapeutic efforts. Importantly, disease presentation can be regulated by genetic modifiers, that may also be therapeutically leverageable. Here, we summarize recent insights into how Jag1 controls processes of relevance to Alagille syndrome, focused on Jag1/ Notch functions in hepatic and cardiovascular development and homeostasis.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10605 - Developmental biology
Result continuities
Project
<a href="/en/project/EH22_010%2F0002902" target="_blank" >EH22_010/0002902: MSCA Fellowships CZ - Charles University</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Cell Biology
ISSN
0955-0674
e-ISSN
1879-0410
Volume of the periodical
86
Issue of the periodical within the volume
únor
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
102302
UT code for WoS article
001154778900001
EID of the result in the Scopus database
2-s2.0-85182188559