The Role of Two Tyrosinase-Like Glycoenzymes in Defining the Final Hue of Parrot Plumage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10498077" target="_blank" >RIV/00216208:11310/25:10498077 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11320/25:10498077
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=omkfqIlLLC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=omkfqIlLLC</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/pcmr.70010" target="_blank" >10.1111/pcmr.70010</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Two Tyrosinase-Like Glycoenzymes in Defining the Final Hue of Parrot Plumage
Original language description
Recent advances in avian melanogenesis have pinpointed multiple genetic loci associated with color polymorphisms, predominantly in the plumage of chickens, quails, and pigeons. However, the genetic basis of melaninization in parrot plumage remains elusive. Previously, we showed that mutations in the melanosomal ion-transporter SLC45A2 lead to a complete loss of blue structural color in green parrot feathers, leaving only yellow psittacofulvin. Yet, several color morphs involving partial or complete melanin reduction are common in captive-bred parrots that have not been studied. To bridge this gap, we investigated two new color morphs of parrot plumage: non-sex-linked recessive lutino (NSL), which entirely inhibits blue structural coloration, and the sex-linked recessive cinnamon, which reduces the intensity of blue structural coloration. Our genotypic analysis revealed that tyrosinase (TYR) variants are responsible for the NSL phenotype in Fischer's lovebird and green-cheeked parakeet, while tyrosinase related protein 1 (TYRP1) variants are associated with the cinnamon phenotype in the rose-ringed parakeet. When transfected into HEK293T cells, the candidate substitutions significantly affected tyrosinase enzymatic activity. This study underscores tyrosinase and related enzymes' role in parrot feather coloration, enhancing our understanding of avian melanogenesis as well as the conserved functions of melanogenic components across different species.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pigment Cell and Melanoma Research
ISSN
1755-1471
e-ISSN
1755-148X
Volume of the periodical
38
Issue of the periodical within the volume
3
Country of publishing house
DK - DENMARK
Number of pages
15
Pages from-to
e70010
UT code for WoS article
001460968700001
EID of the result in the Scopus database
2-s2.0-105002138313