C–H amination of enolizable and nonenolizable ketones

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10512240" target="_blank" >RIV/00216208:11310/25:10512240 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5oAgb3G0li" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5oAgb3G0li</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d5ob00009b" target="_blank" >10.1039/d5ob00009b</a>

Result language

angličtina

Original language name

C–H amination of enolizable and nonenolizable ketones

Original language description

We present a method for the amination of enolizable and non-enolizable ketones in the alpha (or beta) position to the carbonyl group. This approach is based on the conversion of the corresponding cyanohydrins to carbonazidates, precursors for thermal intramolecular nitrene insertion reactions into the adjacent C-H bond. Hydrolysis of the resulting carbamates under basic conditions with simultaneous regeneration of the carbonyl group yields amino ketones.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10401 - Organic chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Organic and Biomolecular Chemistry

ISSN

1477-0520

e-ISSN

1477-0539

Volume of the periodical

23

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

2818-2822

UT code for WoS article

001428211800001

EID of the result in the Scopus database

2-s2.0-105001089648