Development of a Sensitive and Cost-Effective MWCNTs/CCE Sensor for Electrochemical Determination of Prednisolone in Pharmaceuticals and Blood Serum
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10515696" target="_blank" >RIV/00216208:11310/25:10515696 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=U4f3g7bTp4" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=U4f3g7bTp4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/chemosensors13120404" target="_blank" >10.3390/chemosensors13120404</a>
Alternative languages
Result language
angličtina
Original language name
Development of a Sensitive and Cost-Effective MWCNTs/CCE Sensor for Electrochemical Determination of Prednisolone in Pharmaceuticals and Blood Serum
Original language description
A sensitive and cost-effective voltammetric sensor using a carbon-containing electrode (CCE) with a renewable surface modified with multi-walled carbon nanotubes (MWCNTs) was developed for the determination of prednisolone in pharmaceuticals and blood serum. The morphological effects of the functionalization process on the MWCNTs were investigated by transmission electron microscopy (TEM). Analysis of the micrographs indicated that the functionalized nanotubes exhibited a higher density of surface defects and a reduced tendency to form bundles compared to their pristine counterparts. Energy dispersive spectrometry (EDS) confirmed that residual iron particles were removed from the MWCNTs during acid functionalization, demonstrating their intrinsic conductivity. The MWCNTs/CCE was characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The electrochemical behavior of prednisolone in Britton-Robinson buffer at the MWCNTs/CCE was investigated by linear sweep cathodic voltammetry, while the quantitative determination was performed by differential pulse voltammetry (DPV). Under optimal conditions, the sensor exhibited a linear concentration range from 0.04 to 0.6 mu M with a detection limit of 8 nM. The proposed method was successfully applied in the determination of prednisolone in pharmaceutical formulations and blood serum.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemosensors
ISSN
2227-9040
e-ISSN
2227-9040
Volume of the periodical
13
Issue of the periodical within the volume
12
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
404
UT code for WoS article
001646227500001
EID of the result in the Scopus database
2-s2.0-105026094383