Substrate-Independent Approach for the Generation of Functional Protein Resistant Surfaces

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F11%3A10104989" target="_blank" >RIV/00216208:11320/11:10104989 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/11:00359207

Result on the web

<a href="http://pubs.acs.org/doi/abs/10.1021/bm101406m" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/bm101406m</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/bm101406m" target="_blank" >10.1021/bm101406m</a>

Result language

angličtina

Original language name

Substrate-Independent Approach for the Generation of Functional Protein Resistant Surfaces

Original language description

A new route for coating various substrates with antifouling polymer layers was developed. Polymer brushes of hydroxy- and methoxy-capped oligoethyleneglycol methacrylate and carboxybetaine acrylamide were grafted from bromoisobutyrate initiator attachedto a 15 nm thick amino-rich adhesion layer deposited on diverse substrates by RF magnetron sputtering of Nylon 6,6. Well-controlled polymerization kinetics made it possible to control the thickness of the brushes at a nanometer scale. Zero fouling from single protein solutions and a reduction of more than 90% in the fouling from blood plasma observed oh the uncoated surfaces was achieved. The feasibility of functionalization with bioactive compounds was tested by covalent attachment of streptavidin ontopoly(oligoethylene glycol methacrylate) brush and subsequent immobilization of model antibodies and "oligonudecitides.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BM - Solid-state physics and magnetism

OECD FORD branch

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Project

<a href="/en/project/KAN200670701" target="_blank" >KAN200670701: Surface plasmon resonance biosensors and protein arrays for medical diagnostics</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomacromolecules

ISSN

1525-7797

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1058-1066

UT code for WoS article

000289223500024

EID of the result in the Scopus database

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