Synthesis and properties of ApA analogues with shortened phosphonate internucleotide linkage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F11%3A10107371" target="_blank" >RIV/00216208:11320/11:10107371 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/11:00364307
Result on the web
<a href="http://www.tandfonline.com/doi/abs/10.1080/15257770.2011.581259?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed" target="_blank" >http://www.tandfonline.com/doi/abs/10.1080/15257770.2011.581259?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15257770.2011.581259" target="_blank" >10.1080/15257770.2011.581259</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and properties of ApA analogues with shortened phosphonate internucleotide linkage
Original language description
A complete series of the 2'-5' and 3'-5' regioisomeric types of r(ApA) and 2'-d(ApA) analogues with the a-hydroxy-phosphonate C3'-O-P-CH(OH)-C4" internucleotide linkage, isopolar but non-isosteric with the phosphodiester one, were synthesized and their hybridization properties with polyU studied. Due to chirality on the 5'-carbon atom of the modified internucleotide linkage, each regioisomeric type of ApA dimer is split into epimeric pairs. The role of 5'-hydroxyl of the a-hydroxy-phosphonate moiety during hybridization was studied. NMR conformational study on modified sugar-phosphate backbone, along with hybridization measurements and MDS, revealed remarkable differences in the stability of complexes with polyU, depending on the 5'-carbon atom configuration.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
524-543
UT code for WoS article
000296072200007
EID of the result in the Scopus database
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