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Study of Cellular Uptake of Modified Oligonucleotides by Using Time-Resolved Microspectrofluorimetry and Florescence Imaging

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F12%3A10128431" target="_blank" >RIV/00216208:11320/12:10128431 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1155/2012/415496" target="_blank" >http://dx.doi.org/10.1155/2012/415496</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2012/415496" target="_blank" >10.1155/2012/415496</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Study of Cellular Uptake of Modified Oligonucleotides by Using Time-Resolved Microspectrofluorimetry and Florescence Imaging

  • Original language description

    Fluorescence microimaging and homodyne phase-resolved confocal microspectrofluorimetry were used to monitor the transport of antisense oligonucleotide into cancer MCF7 cells and the subsequent intracellular distribution. Phosphorothioate analog of 15-meroligoadenylate (dA(15)) labeled by ATTO 425 was complexed with 5,10,15,20-tetrakis (1-methyl-4-pyridyl) porphyrin (H(2)TMPyP4) as an uptake-mediating agent. Fluorescence lifetime data within a broad spectral range have revealed properties of both components inside the cell. H(2)TMPyP4 lifetime inside the cell is not influenced in this malignant cell line, while the lifetime of modified oligonucleotide was found to be slightly shortened.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP208%2F10%2F0941" target="_blank" >GAP208/10/0941: Engineering of surface-modified optical processes in molecules and semiconductor quantum dots by plasmon resonances in metal nanoparticle assemblies.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    SPECTROSCOPY-AN INTERNATIONAL JOURNAL

  • ISSN

    0712-4813

  • e-ISSN

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    5-6

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    5

  • Pages from-to

    415-419

  • UT code for WoS article

    000306505500020

  • EID of the result in the Scopus database