Infliximab trough levels may predict sustained response to infliximab in patients with Crohn's disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F13%3A10144237" target="_blank" >RIV/00216208:11320/13:10144237 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/13:10144237 RIV/00064165:_____/13:10144237
Result on the web
<a href="http://www.ecco-jccjournal.org/article/S1873-9946(12)00456-4/abstract" target="_blank" >http://www.ecco-jccjournal.org/article/S1873-9946(12)00456-4/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.crohns.2012.10.019" target="_blank" >10.1016/j.crohns.2012.10.019</a>

Result language
angličtina
Original language name
Infliximab trough levels may predict sustained response to infliximab in patients with Crohn's disease
Original language description
Background and aims: Over 10% of Crohn's disease (CD) patients annually lose response to infliximab. Infliximab trough levels (TL), concomitant immunosuppressants and endoscopic healing were proposed as predictors of favourable infliximab outcome. We assessed infliximab TL measured after induction therapy as predictors of sustained clinical response. Furthermore, we tried to identify other predictors of long-term benefit of infliximab therapy. Methods: We included CD patients treated with infliximab between October 2007 and March 2010 who responded to 3-dose induction followed by maintenance therapy and in whom blood samples taken at treatment week 14 or 22 were available in blood bank. Sustained response to infliximab was defined as absence of treatment failure due to loss of response or drug intolerance. Results: Eighty four patients were included. Sustained response to infliximab was observed in 47 (56%) patients during a median follow-up of 25 months (14-37). lnfliximab TL>3 mu g/m
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BB - Applied statistics, operational research
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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