Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F13%3A10172645" target="_blank" >RIV/00216208:11320/13:10172645 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/13:10172645 RIV/00064203:_____/13:10172645 RIV/00216208:11120/13:43907608

Result on the web

<a href="http://dx.doi.org/10.1155/2013/718254" target="_blank" >http://dx.doi.org/10.1155/2013/718254</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2013/718254" target="_blank" >10.1155/2013/718254</a>

Result language

angličtina

Original language name

Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness

Original language description

Aim. GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore,investigated the carotid intima-media thickness (CIMT) as an indicator of macrovascular complications in a group of patients with GCK-MODY. Methods. Twenty-seven GCK mutation carriers and 24 controls recruited among their first-degree relatives were compared, all aging over 35 years. The CIMT was tested using a high-resolution B-mode carotid ultrasonography. Medical history, anthropometry, and biochemical blood workup were obtained. Results. The mean CIMT was 0.707 +/- 0.215mm (mean +/- SD) in GCK mutation carriers and 0.690 +/- 0.180mm in control individuals. When adjusted for age, gender, and family status, the estimated mean difference in CIMT between the two groups increased to 0.049mm (P = 0.19). No difference was detected for othe

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT11402" target="_blank" >NT11402: Genetic investigation of monogenic diabetes in the Czech Republic: Evaluation of clinical symptoms, treatment and quality of life</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Endocrinology

ISSN

1687-8337

e-ISSN

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Volume of the periodical

2013

Issue of the periodical within the volume

Léto

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

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UT code for WoS article

000324702500001

EID of the result in the Scopus database

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