The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F15%3A10294691" target="_blank" >RIV/00216208:11320/15:10294691 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/15:10294691 RIV/00216208:11160/15:10294691 RIV/00179906:_____/15:10294691
Result on the web
<a href="http://link.springer.com/article/10.1007/s00296-015-3219-z/fulltext.html" target="_blank" >http://link.springer.com/article/10.1007/s00296-015-3219-z/fulltext.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00296-015-3219-z" target="_blank" >10.1007/s00296-015-3219-z</a>
Alternative languages
Result language
angličtina
Original language name
The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients
Original language description
Some single-nucleotide polymorphisms (SNPs) might be predictive of methotrexate (MTX) therapeutic outcome in rheumatoid arthritis (RA). The aim of this study was to determine whether SNPs in the methylenetetrahydrofolate reductase (MTHFR) gene are predictive of MTX response. Comparison was made using EULAR response criteria and according to the change of DAS28 (DeltaDAS28) after a 6-month MTX treatment in RA patient cohort. The two SNPs C677T (rs1801133) and A1298C (rs1801131) have been genotyped. A total of 120 patients were enrolled in the study, and all of them fulfilled the American College of Rheumatology 1987 RA criteria and are currently or previously taking MTX oral treatment, either as a monotherapy (n=65) or in a combination with other disease-modifying antirheumatic drugs (n=55). Genotyping was performed using qPCR allelic discrimination. We did not found any association of C677T and A1298C genotypes with MTX treatment inefficacy in dominant model (OR 1.23, 95 % CI 0.57-2.65
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Rheumatology International
ISSN
0172-8172
e-ISSN
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Volume of the periodical
35
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
1149-1161
UT code for WoS article
000354709500005
EID of the result in the Scopus database
2-s2.0-84929839397