Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F15%3A10316036" target="_blank" >RIV/00216208:11320/15:10316036 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fmicb.2015.00783" target="_blank" >http://dx.doi.org/10.3389/fmicb.2015.00783</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmicb.2015.00783" target="_blank" >10.3389/fmicb.2015.00783</a>

Result language
angličtina
Original language name
Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives
Original language description
Three structurally related oxathiolone fused chalcone derivatives appeared effective chemosensitizers, able to restore in part sensitivity to fluconazole of multidrug-resistant C. albicans strains. Compound 21 effectively chemosensitized cells resistantdue to the overexpression of the MDFR1 gene, compound 6 reduced resistance of cells overexpressing the ABC-type drug transporters CDFR1/CDFR2 and derivative 18 partially reversed fluconazole resistance mediated by both types of yeast drug efflux pumps. The observed effect of sensitization of resistant strains of Candida albicans to fluconazole activity in the presence of active compounds most likely resulted from inhibition of the pump-mediated efflux, as was revealed by the results of studies involvingthe fluorescent probes, Nile Red, Rhodamine 6G and diS-C-3(3).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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