Evaluation of Total Hepatocellular Cancer Lifespan, Including Both Clinically Evident and Preclinical Development, Using Combined Network Phenotyping Strategy and Fisher Information Analysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F15%3A10319693" target="_blank" >RIV/00216208:11320/15:10319693 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1053/j.seminoncol.2014.12.025" target="_blank" >http://dx.doi.org/10.1053/j.seminoncol.2014.12.025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1053/j.seminoncol.2014.12.025" target="_blank" >10.1053/j.seminoncol.2014.12.025</a>

Result language
angličtina
Original language name
Evaluation of Total Hepatocellular Cancer Lifespan, Including Both Clinically Evident and Preclinical Development, Using Combined Network Phenotyping Strategy and Fisher Information Analysis
Original language description
We previously showed that for hepatocellular cancer (HCC) prognostication, disease parameters need to be considered within a total personal clinical context. This requires preserving the coherence of data values, observed simultaneously for each patientduring baseline diagnostic evaluation. Application of the Network Phenotyping Strategy (NPS) provided quantitative descriptors of these patient coherences. Combination of these descriptors with Fisher information about the patient tumor mass and the histogram of the tumor masses in the whole cohort permitted estimation of the time from disease onset until clinical diagnosis (t(baseline)). We found faster growth of smaller tumors having total masses <70 (80% of cohort) which involved about three times more interacting cellular processes than were observed for slower growing larger tumors (20% of cohort) with total masses >70. Combining the clinical survival and tbasth normalized all HCC patients to a common 1,045 days of mean total disea
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BB - Applied statistics, operational research
OECD FORD branch
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Project
<a href="/en/project/LL1201" target="_blank" >LL1201: Complex Structures: Regularities in Combinatorics and Discrete Mathematics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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