Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F18%3A10389195" target="_blank" >RIV/00216208:11320/18:10389195 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/18:00489284
Result on the web
<a href="https://doi.org/10.1126/scisignal.aan8621" target="_blank" >https://doi.org/10.1126/scisignal.aan8621</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/scisignal.aan8621" target="_blank" >10.1126/scisignal.aan8621</a>
Alternative languages
Result language
angličtina
Original language name
Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel
Original language description
Transient receptor potential ankyrin 1 (TRPA1) is a temperature-sensitive ion channel activated by various pungent and irritant compounds that can produce pain in humans. Its activation involves an allosteric mechanism whereby electrophilic agonists evoke interactions within cytosolic domains and open the channel pore through an integrated nexus formed by intracellular membrane proximal regions that are densely packed beneath the lower segment of the S1-S4 sensor domain. Studies indicate that this part of the channel may contain residues that form a water-accessible cavity that undergoes changes in solvation during channel gating. We identified conserved polar residues facing the putative lower crevice of the sensor domain that were crucial determinants of the electrophilic, voltage, and calcium sensitivity of the TRPA1 channel. This part of the sensor may also comprise a domain capable of binding to membrane phosphoinositides through which gating of the channel is regulated in a state-dependent manner.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GA15-15839S" target="_blank" >GA15-15839S: Regulatory mechanisms of nociceptive transient receptor potential ion channels</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Signaling
ISSN
1945-0877
e-ISSN
—
Volume of the periodical
11
Issue of the periodical within the volume
514
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
—
UT code for WoS article
000423100700003
EID of the result in the Scopus database
2-s2.0-85041031781