Mechanical and biocorrosive properties of magnesium-aluminum alloy scaffold for biomedical applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F19%3A10405472" target="_blank" >RIV/00216208:11320/19:10405472 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kzB_KQ5bH_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kzB_KQ5bH_</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmbbm.2019.06.022" target="_blank" >10.1016/j.jmbbm.2019.06.022</a>
Alternative languages
Result language
angličtina
Original language name
Mechanical and biocorrosive properties of magnesium-aluminum alloy scaffold for biomedical applications
Original language description
This study investigates the morphology, microstructure, compressive behavior, biocorrosion properties, and cytocompatibility of magnesium (Mg)-aluminum (Al) alloy (AE42) scaffolds for their potential use in biodegradable biomedical applications. Mg alloy scaffolds were successfully synthesized via a camphene-based freeze casting process with precisely controlled heat treatment. The average porosity was approximately 52% and the median pore diameter was similar to 13 mu m. Salient deformation mechanisms were identified using acoustic emission (AE) signals and adaptive sequential k-means (ASK) analysis. Twinning, dislocation slip, strut bending, and collapse were dominant during compressive deformation. Nonetheless, the overall compressive behavior and deformation mechanisms were similar to those of bulk Mg based on ASK analysis. The corrosion potential of the Mg alloy scaffold (-1.44 V) was slightly higher than that of bulk AE42 (-1.60 V), but the corrosion rate of the Mg alloy scaffold was faster than that of bulk AE42 due to the enhanced surface area of the Mg alloy scaffold. As a result of cytocompatibility evaluation following ISO10993-5, the concentration of the Mg alloy scaffold extract reducing cell growth rate to 50% (IC50) was 10.7%, which is higher (less toxic) than 5%, suggesting no severe inflammation by implantation into muscle.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
<a href="/en/project/GA15-10821S" target="_blank" >GA15-10821S: Size effect in plastic deformation of materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the Mechanical Behavior of Biomedical Materials
ISSN
1751-6161
e-ISSN
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Volume of the periodical
98
Issue of the periodical within the volume
98
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
213-224
UT code for WoS article
000483637900025
EID of the result in the Scopus database
2-s2.0-85068104198