AHoJ: rapid, tailored search and retrieval of apo and holo protein structures for user-defined ligands
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F22%3A10455491" target="_blank" >RIV/00216208:11320/22:10455491 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10455491
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=grImfWUyVa" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=grImfWUyVa</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/bioinformatics/btac701" target="_blank" >10.1093/bioinformatics/btac701</a>
Alternative languages
Result language
angličtina
Original language name
AHoJ: rapid, tailored search and retrieval of apo and holo protein structures for user-defined ligands
Original language description
SummaryUnderstanding the mechanism of action of a protein or designing better ligands for it, often requires access to a bound (holo) and an unbound (apo) state of the protein. Resources for the quick and easy retrieval of such conformations are severely limited. Apo-Holo Juxtaposition (AHoJ), is a web application for retrieving apo-holo structure pairs for user-defined ligands. Given a query structure and one or more user-specified ligands, it retrieves all other structures of the same protein that feature the same binding site(s), aligns them, and examines the superimposed binding sites to determine whether each structure is apo or holo, in reference to the query. The resulting superimposed datasets of apo-holo pairs can be visualized and downloaded for further analysis. AHoJ accepts multiple input queries, allowing the creation of customized apo-holo datasets.Availability and implementationFreely available for non-commercial use at http://apoholo.cz. Source code available at https://github.com/cusbg/AHoJ-project.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
<a href="/en/project/LM2018131" target="_blank" >LM2018131: Czech National Infrastructure for Biological Data</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioinformatics
ISSN
1367-4803
e-ISSN
1367-4811
Volume of the periodical
38
Issue of the periodical within the volume
24
Country of publishing house
GB - UNITED KINGDOM
Number of pages
2
Pages from-to
5452-5453
UT code for WoS article
000879491300001
EID of the result in the Scopus database
2-s2.0-85144588470