Chiral Gold Nanoparticles via L- or D-Cysteine Functionalization: Synthesis and Characterization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F25%3A10510643" target="_blank" >RIV/00216208:11320/25:10510643 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5Rj-u4mMAg" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5Rj-u4mMAg</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cplu.202500027" target="_blank" >10.1002/cplu.202500027</a>

Result language

angličtina

Original language name

Chiral Gold Nanoparticles via L- or D-Cysteine Functionalization: Synthesis and Characterization

Original language description

Chirality, the property of objects being nonsuperimposable on their mirror image, is critical in natural phenomena and technological applications, particularly molecular interactions and biological processes. The achievement of nanoscale chirality has led to the development of gold nanoparticles (AuNPs) with transformative potential in sensing and biosensing, which may find applications in theranostics and drug-contaminated water treatment. Herein, a wet synthesis approach for chiral AuNPs using L- or D-cysteine, a chiral amino acid, is presented. The synthesis begins with small gold spheres, then functionalized with L- or D-cysteine, which binds selectively to kink sites, inducing a twisted shape. These functionalized AuNPs inherit chiral properties, enabling selective interactions with biomolecules, enhancing sensitivity and specificity for detecting enantiomers and biomarkers. Microscopy reveals the twisted shape, dynamic light scattering confirms stability over months, X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy validate successful cysteine functionalization, and finally, circular dichroism spectroscopy confirms optical activity in correspondence to both the molecular absorption and the nanoparticle surface plasmon resonance. These optically active AuNPs demonstrate significant promise for molecular diagnostics and environmental sensing, offering new frontiers in biomedical and environmental applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10305 - Fluids and plasma physics (including surface physics)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ChemPlusChem

ISSN

2192-6506

e-ISSN

—

Volume of the periodical

90

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

e202500027

UT code for WoS article

001525847300001

EID of the result in the Scopus database

2-s2.0-105010236264